Parkinson's disease: Cause, Symptom, Treatment
1) Cause: Substantia nigra (pars compacta, dopamin neuron death)--->Extreme excitation of GPi

2) Symptom:
akinesia, rigidity, resting tremor, loss of the modulation of speech
long reaction time, difficulty in the anticipatory adjustment of posture
error in tracking movement, difficulty in simultaneous execution of two movement
the depicient planning of movement

3) Treatment for akinesia: L-Dopa
*decarboxylase inhibitor
*Ach antagonist(atropine)
1. Replacement 2. Substitution, 3. Relase helper 4. Conservation

*fetal dopamine cell transplantation
* destruction of feed-back circuit: ventrolateral, ventroanterior nuclei